Base de dados : HANSEN Pesquisa : CELULAS DE SCHWANN/ULTRAEST [Descritor de assunto] Referências encontradas : 6 [refinar] Mostrando: 1 .. 6   no formato [Detalhado]

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Id: 18643 Autor: Hagge, Deanna A; Robinson, Sandra Oby; Scollard, David; McCormick, Gregory; Williams, Diana L Título: A new model for studyng the effects of Mycobacterium leprae on Schwann cell and neuron interactions ..- Fonte: s.l; s.n; 2002. 14 p. ilus, tab. Resumo: Millions of patients with leprosy suffer from nerve damage resulting in disabilities as a consequence of Mycobacterium leprae infection. However, mechanisms of nerve damage have not been elucidated because of the lack of a model that maintains M. leprae viability and mimics disease conditions. A model was developed using viable M. leprae, rat Schwann cells, and Schwann cell-neuron cocultures incubated at 33 degrees C. M. leprae retained 56 per cente viability in Schwann cells for 3 weeks after infection at 33 degrees C, compared with 3.6 per cente viability at 37 degrees C. Infected Schwann cells had altered morphology and expression of genes encoding cellular adhesion molecules at 33 degrees C but were capable of interacting with and myelinating neurons. Cocultures, infected after myelination occurred, showed no morphological changes in myelin architecture after 1 month of incubation at 33 degrees C, and M. leprae retained 53 per cente viability. This article describes a new model for studying the effects of M. leprae on Schwann cells. (AU). Descritores: CAMUNDONGOS NUS HANSENIASE/microbiol HANSENIASE/patol MODELOS NEUROLOGICOS MICROSCOPIA ELETRÔNICA DE VARREDURA CELULAS CULTIVADAS NEURÔNIOS/microbiol NEURÔNIOS/patol NEURÔNIOS/fisiol COMUNICACAO CELULAR/fisiol MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/fisiol CELULAS DE SCHWANN/microbiol CELULAS DE SCHWANN/patol CELULAS DE SCHWANN/fisiol CELULAS DE SCHWANN/ultraest Limites: HUMANO ANIMAL CAMUNDONGOS RATOS SUPPORT, NON-U.S. GOV'T Meio Eletrônico: - . Localização: BR191.1; 09030/s

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Id: 18340 Autor: Hagge, Deanna; Robinson, Sandra Oby; Scollard, David; McCormick, Gregory; Williams, Diana L Título: A new model for studying the effects of Mycobacterium leprae on Schwann cell and neuron interactions ..- Fonte: s.l; s.n; 2002. 4 p. tab. Resumo: Millions of patients with leprosy suffer from nerve damage resulting in disabilities as a consequence of Mycobacterium leprae infection. However, mechanisms of nerve damage have not been elucidated because of the lack of a model that maintains M. leprae viability and mimics disease conditions. A model was developed using viable M. leprae, rat Schwann cells, and Schwann cell-neuron cocultures incubated at 33 degrees C. M. leprae retained 56% viability in Schwann cells for 3 weeks after infection at 33 degrees C, compared with 3.6% viability at 37 degrees C. Infected Schwann cells had altered morphology and expression of genes encoding cellular adhesion molecules at 33 degrees C but were capable of interacting with and myelinating neurons. Cocultures, infected after myelination occurred, showed no morphological changes in myelin architecture after 1 month of incubation at 33 degrees C, and M. leprae retained 53% viability. This article describes a new model for studying the effects of M. leprae on Schwann cells. (AU). Descritores: COMUNICACAO CELULAR/fisiol CELULAS CULTIVADAS HANSENIASE/microbiol HANSENIASE/patol CAMUNDONGOS NUS MODELOS NEUROLOGICOS NEURÔNIOS/microbiol NEURÔNIOS/patol NEURÔNIOS/fisiol CELULAS DE SCHWANN/microbiol CELULAS DE SCHWANN/patol CELULAS DE SCHWANN/fisiol CELULAS DE SCHWANN/ultraest MICROSCOPIA ELETRÔNICA DE VARREDURA MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/fisiol Limites: ANIMAL HUMANO CAMUNDONGOS RATOS SUPPORT, NON-U.S. GOV'T Localização: BR191.1; 08982/s

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Id: 18026 Autor: Anthony, J; Vaidya, M. C; Dasgupta, A Título: Ultrastructure of nerve in erythema nodosum leprosum (ENL) ..- Fonte: s.l; s.n; 1979. 4 p. ilus. Resumo: Gross changes of myelinated fibres and Schwann cells at different degenerative stages were present in all five ENL nerve lesions. Besides these changes, infiltrating cells mainly macrophages, deposition of excessive collagen and perineurial vessel damage were also observed.(AU). Descritores: CELULAS DE SCHWANN/ultraest ERITEMA NODOSO/patol HANSENIASE/patol DEGENERACAO NEURAL FIBRAS NERVOSAS MIELINIZADAS/ultraest - SISTEMA NERVOSO/ultraest  COLAGENO  ORELHA/inerv  MICROSCOPIA ELETRÔNICA  CELULAS SANGUINEAS Limites: HUMANO Meio Eletrônico: - . Localização: BR191.1; 01060/s

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Id: 17780 Autor: Shetty, V. P; Mehta, L. N; Irani, P. F; Antia, N. H Título: Study of the evolution of nerve damage in leprosy. Part I--Lesions of the index branch of the radial cutaneous nerve in early leprosyStudy of evolution of nerve damage in leprosy. Part II--Observations on the index branch of the radial cutaneous nerve in contacts of leprosy ..- Fonte: s.l; s.n; jan. 1980. 14 p. tab, graf, ilus. Resumo: A total of six index finger branch of the radial cutaneous (IRC) nerves from three BL, two BB and one BT cases of leprosy, with less than 6 months history of disease were subjected for nerve conduction velocity (NCV) studies followed by biopsy. The biopsy was divided into three parts and subjected for light microscopy quantitative histology, electron-microscopy and fibre tease studies. The nerves revealed a slight reduction in NCV and a varying degree of segmental demyelination ranging from 10% to 35%. The earliest changes observed were the thickening and proliferation of Schwann cell processes of the unmyelinated fibres and degeneration of their axons regardless of the type of leprosy.(AU) A total of 35 contacts from 20 families of lepromatous index cases were screened clinically. All of them were subjected for nerve conduction velocity (NCV) studies of both left and right index branch of the radial cutaneous (IRC) nerve. Fifteen of these nerves were biopsied. Out of 15 IRC nerves biopsied 10 had slightly reduced average NCV values and 5 were normal. Four nerves out of 10 where average NCV was reduced and 1 nerve out of 5 where NCV was normal showed significant ultrastructural changes and higher percentage of segmental demyelination (10%--13%). There was a striking similarity between the changes seen in the IRC nerves of early cases of leprosy and of contacts.(AU). Descritores: PELE/irrig FATORES DE TEMPO HANSENIASE/patol DEGENERACAO NEURAL FIBRAS NERVOSAS/ultraest CONDUCAO NERVOSA NERVO RADIAL/patol NERVO RADIAL/ultraest DEDOS/irrig HANSENIASE/diag HANSENIASE/genet CELULAS DE SCHWANN/ultraest Limites: MASCULINO FEMININO ADOLESCENTE ADULTO CRIANCA HUMANO MEIA-IDADE Meio Eletrônico: - . Localização: BR191.1; 01984/s

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Id: 13376 Autor: Tzourio, Christophe; Said, Gerard; Millan, Jacques Título: Asymptomatic nerve hypertrophy in lepromatous leprosy: a clinical, electrophysiological and morphological study ..- Fonte: s.l; s.n; 1992. 8 p. ilus, tab. Descritores: POTENCIAIS DE AÇAO CITOPLASMA ELETROFISIOLOGIA ENDOTÉLIO VASCULAR FIBROBLASTOS HIPERTROFIA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA MICROSCOPIA ELETRONICA BAINHA DE MIELINA CONDUÇAO NERVOSA NERVO RADIAL NERVO RADIAL VALORES DE REFERENCIA CÉLULAS DE SCHWANN Localização: BR191.1; 06417/s

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Id: 5715 Autor: Job, C. K; Verghese, Roy Título: Schwann cell changes in lepromatous leprosy - electronmicroscope study ..- Fonte: s.l; s.n; 1975. 4 p. ilus. Descritores: HANSENIASE HANSENIASE MYCOBACTERIUM LEPRAE CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN Localização: BR191.1; 02680/s

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